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However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise

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These challenges have led to increased interest in innovative therapeutic approaches, such as MSC-Exos, which are naturally biocompatible and possess diverse cytoprotective characteristics (Fig

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